HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice.

Abstract

The current results provide direct evidence for protective roles of HIF-1 induction in the development of ethanol-induced fatty liver via activation of the HIF-1-regulated transcriptional repressor DEC1.

Full Text

• DOI - Journal of Hepatology (DOI)
• Swets Information Services - full-text online
• OhioLINK Electronic Journal Center - full-text online
• Elsevier Science - full-text online
• EBSCO - full-text online

Subjects

• Acetyl-CoA Carboxylase
• Amino Acids, Dicarboxylic
• Animals
• Basic Helix-Loop-Helix Transcription Factors
• Disease Susceptibility
• Ethanol
• Fatty Liver, Alcoholic
• Gene Expression
• Homeodomain Proteins
• Hypoxia-Inducible Factor 1, alpha Subunit
• Lipid Metabolism
• Liver
• Male
• Mice
• Mice, Knockout
• Sterol Regulatory Element Binding Protein 1

Similar articles

• Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice. (2011-04-26)
• CYP2E1 Potentiates Ethanol-induction of Hypoxia and HIF-1α in vivo. (2013-05-10)
• Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis. (2011-07-27)
• Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. (2009-07-27)
• Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. (2003-01-29)
• Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death. (2011-05-05)
• Baicalein induces functional hypoxia-inducible factor-1alpha and angiogenesis. (2008-06-20)
• Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function. (2012-12-19)
• CITED2 mediates the paradoxical responses of HIF-1alpha to proteasome inhibition. (2008-03-20)

Authors

• Yasumasa Nishiyama
• Nobuhito Goda
• Mai Kanai
• Daisuke Niwa
• Kota Osanai
• Yu Yamamoto
• Nanami Senoo-Matsuda
• Randall S Johnson
• Soichiro Miura
• Yasuaki Kabe
• Makoto Suematsu

Publication date

2012-01-18

Journal

Journal topics

• Liver
• Liver Diseases

Language

Eng.

Copyright

Journal of Hepatology

Department of Biochemistry, School of Medicine, Keio University, Tokyo, Japan.

Release reference

J Hepatol. 2012 Feb;56(2):441-7

Related books

• Books of Acetyl-CoA Carboxylase
• Books of Amino Acids, Dicarboxylic
• Books of Animals
• Books of Basic Helix-Loop-Helix Transcription Factors
• Books of Disease Susceptibility
• Books of Ethanol
• Books of Fatty Liver, Alcoholic
• Books of Gene Expression
• Books of Homeodomain Proteins
• Books of Hypoxia-Inducible Factor 1, alpha Subunit
• Books of Lipid Metabolism
• Books of Liver
• Books of Liver
• Books of Liver Diseases
• Books of Mice
• Books of Mice, Knockout
• Books of Sterol Regulatory Element Binding Protein 1