Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children.

Abstract

We have identified multiple genetic variants in SLC28A3 and other genes associated with ACT. Combined with clinical risk factors, genetic risk profiling might be used to identify high-risk patients who can then be provided with safer treatment options.

Full Text

• DOI - Journal of clinical oncology : official journal of the American Society of Clinical Oncology (DOI)
• HighWire Press - full-text online
• EBSCO - full-text online

Subjects

• ATP-Binding Cassette Transporters
• Adolescent
• Age Factors
• Anthracyclines
• Antibiotics, Antineoplastic
• Biotransformation
• Canada
• Child
• Child, Preschool
• Female
• Genetic Association Studies
• Genetic Predisposition to Disease
• Heart Diseases
• Humans
• Infant
• Infant, Newborn
• Kaplan-Meier Estimate
• Male
• Membrane Transport Proteins
• Neoplasms
• Netherlands
• Odds Ratio
• Pharmacogenetics
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Assessment
• Risk Factors

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Authors

• Henk Visscher
• Colin J D Ross
• S Rod Rassekh
• Amina Barhdadi
• Marie-Pierre Dubé
• Hesham Al-Saloos
• George S Sandor
• Huib N Caron
• Elvira C van Dalen
• Leontien C Kremer
• Helena J van der Pal
• Andrew M K Brown
• Paul C Rogers
• Michael S Phillips
• Michael J Rieder
• Bruce C

Publication date

2012-04-30

Journal

Journal topics

• Medical Oncology

Language

Eng.

Copyright

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

University of British Columbia, Vancouver, British Columbia.

Release reference

J Clin Oncol. 2012 May;30(13):1422-8

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