Comparable outcomes in fracture reduction and bone properties with RANKL inhibition and alendronate treatment in a mouse model of osteogenesis imperfecta.

Abstract

Treatment of oim/oim mice with either a bisphosphonate or a RANK-Fc causes similar decreases in fracture incidence with increases in metaphyseal bone volume via increased number of thinner trabeculae.

Full Text

• DOI - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (DOI)
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Subjects

• Acid Phosphatase
• Alendronate
• Animals
• Biomechanics
• Bone Density
• Bone Density Conservation Agents
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Female
• Isoenzymes
• Male
• Mice
• Osteogenesis Imperfecta
• Osteoporotic Fractures
• RANK Ligand
• Recombinant Fusion Proteins
• Weight Gain
• X-Ray Microtomography

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Authors

• R Bargman
• R Posham
• A L Boskey
• E DiCarlo
• C Raggio
• N Pleshko

Publication date

2012-02-13

Journal

Journal topics

• Osteoporosis

Language

Eng.

Copyright

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

NYPH-Weill Cornell Medical Center, New York, NY, USA. rbargman [at] numc.edu

Release reference

Osteoporos Int. 2012 Mar;23(3):1141-50

Related books

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• Books of Biomechanics
• Books of Bone Density
• Books of Bone Density Conservation Agents
• Books of Disease Models, Animal
• Books of Drug Evaluation, Preclinical
• Books of Isoenzymes
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