Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies.

Abstract

Our results clearly showed the antitumor activity of MLN2238 in a variety of mouse models of B-cell lymphoma and PCM, supporting its clinical development. MLN9708 is being evaluated in multiple phase I and I/II trials.

Full Text

• DOI - Clinical cancer research : an official journal of the American Association for Cancer Research (DOI)
• HighWire Press - full-text online

Subjects

• Animals
• Antineoplastic Agents
• Boron Compounds
• Boronic Acids
• Cell Line, Tumor
• Glycine
• Humans
• Lymphoma, B-Cell
• Mice
• Mice, Inbred C57BL
• Mice, Inbred NOD
• Mice, SCID
• Mice, Transgenic
• Neoplasms, Plasma Cell
• Osteolysis
• Protease Inhibitors
• Proteasome Endopeptidase Complex
• Pyrazines
• Xenograft Model Antitumor Assays

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Authors

• Edmund C Lee
• Michael Fitzgerald
• Bret Bannerman
• Jill Donelan
• Kristen Bano
• Jennifer Terkelsen
• Daniel P Bradley
• Ozlem Subakan
• Matthew D Silva
• Ray Liu
• Michael Pickard
• Zhi Li
• Olga Tayber
• Ping Li
• Paul Hales
• Mary Carsillo
• Vishala T Neppalli
• Allison J Berger
• Erik

Publication date

2011-12-02

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Clinical cancer research : an official journal of the American Association for Cancer Research

Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA. Edmund.Lee [at] Roche.com

Release reference

Clin Cancer Res. 2011 Dec;17(23):7313-23

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