Tolerogenic dendritic cells inhibit antiphospholipid syndrome derived effector/memory CD4⁺ T cell response to β2GPI.

Abstract

The inherent tolerance induction resistance of activated T cells present during the development of autoimmune diseases has delayed the application of tDC as an alternative therapy.

This study highlights the 10/TGF-DC feasibility to induce antigen-specific unresponsiveness in autoreactive T cells generated in patients with APS by inducing apoptosis or T cells with regulatory abilities.

Full Text

• DOI - Annals of the rheumatic diseases (DOI)
• Ovid Technologies, Inc. - full-text online
• Lippincott Williams & Wilkins - full-text online
• HighWire Press - full-text online
• EBSCO - full-text online

Subjects

• Adult
• Aged
• Antiphospholipid Syndrome
• CD4-Positive T-Lymphocytes
• Cell Differentiation
• Cell Proliferation
• Cells, Cultured
• Coculture Techniques
• Cytokines
• Dendritic Cells
• Female
• Humans
• Immune Tolerance
• Immunologic Memory
• Immunophenotyping
• Lymphocyte Activation
• Male
• Middle Aged
• beta 2-Glycoprotein I

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Authors

• Honorio Torres-Aguilar
• Miri Blank
• Shaye Kivity
• Mudi Misgav
• Jacob Luboshitz
• Silvia S Pierangeli
• Yehuda Shoenfeld

Publication date

2011-12-02

Journal

Journal topics

• Rheumatic Diseases

Language

Eng.

Copyright

Annals of the rheumatic diseases

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Release reference

Ann Rheum Dis. 2012 Jan;71(1):120-8

Related books

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