Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling.

Abstract

Proteasomal inhibition prevents lung and skin fibrosis after injury in part by increasing the abundance and activity of PPARγ. Proteasomal inhibition may offer a novel therapeutic alternative in patients with dysregulated tissue repair and fibrosis.

Full Text

• DOI - Thorax (DOI)
• Ovid Technologies, Inc. - full-text online
• Lippincott Williams & Wilkins - full-text online
• HighWire Press - full-text online
• EBSCO - full-text online

Subjects

• Animals
• Autocrine Communication
• Bleomycin
• Boronic Acids
• Cells, Cultured
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Female
• Fibroblasts
• Fibrosis
• Gene Expression Regulation
• Humans
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• PPAR gamma
• Proteasome Endopeptidase Complex
• Pulmonary Fibrosis
• Pyrazines
• Scleroderma, Systemic
• Signal Transduction
• Skin
• Transforming Growth Factor beta1

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Authors

• Gökhan M Mutlu
• G R Scott Budinger
• Minghua Wu
• Anna P Lam
• Aaron Zirk
• Stephanie Rivera
• Daniela Urich
• Sergio E Chiarella
• Leonard H T Go
• Asish K Ghosh
• Moises Selman
• Annie Pardo
• John Varga
• David W Kamp
• Navdeep S Chandel
• Jacob Iasha Sznajder
• Manu Jain

Publication date

2012-01-23

Journal

Journal topics

• Thorax

Language

Eng.

Copyright

Thorax

Department of Medicine, Northwestern University, Chicago, Illinois 60611, USA.

Release reference

Thorax. 2012 Feb;67(2):139-46

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