Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects.

Abstract

Our gene-based GWAS confirmed several BMD genes and suggested several novel BMD genes.

Genetic contribution to BMD variation may operate through multiple genes identified in this study in functional gene networks.

This finding may be useful in identifying and prioritizing candidate genes/loci for further study.

Full Text

• DOI - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (DOI)
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Subjects

• Adult
• Aged
• Asian Continental Ancestry Group
• Bone Density
• European Continental Ancestry Group
• Female
• Femur Neck
• Gene Regulatory Networks
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Genotype
• Hong Kong
• Humans
• Iceland
• Lumbar Vertebrae
• Middle Aged
• Osteoporosis
• Polymorphism, Single Nucleotide

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Authors

• C-L Cheung
• P-C Sham
• S-M Xiao
• C H Bow
• A W-C Kung

Publication date

2012-01-02

Journal

Journal topics

• Osteoporosis

Language

Eng.

Copyright

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China. lung1212 [at] hku.hk

Release reference

Osteoporos Int. 2012 Jan;23(1):131-42

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