DOCK8 deficiency and Job's syndrome share several clinical features, including elevated serum IgE levels, dermatitis, recurrent sinopulmonary infections, and cutaneous staphylococcal abscesses. However, the presence of recalcitrant, widespread cutaneous viral infections, asthma, and food and environmental allergies, as well as the absence of newborn rash and coarse facies, favors the clinical diagnosis of DOCK8 deficiency.
Rates of malignancy and overall mortality in patients with DOCK8 deficiency were higher than in those with Job's syndrome, highlighting the value of distinguishing between these conditions and the importance of close monitoring for neoplasia.
2012-01-17
Eng.
Archives of dermatology
Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. emily.chu [at] uphs.upenn.edu
Arch Dermatol. 2012 Jan;148(1):79-84
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