Novel germline PALB2 truncating mutations in African American breast cancer patients.

Abstract

PALB2 mutations were present in both familial and nonfamilial breast cancers among African Americans. Rare PALB2 mutations accounted for a small but substantial proportion of patients with breast cancer.

Full Text

• DOI - Cancer (DOI)
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Subjects

• Adult
• African Americans
• Breast Neoplasms
• Carcinoma
• Codon, Nonsense
• DNA Mutational Analysis
• Family Health
• Female
• Gene Frequency
• Genes, BRCA1
• Genes, BRCA2
• Genetic Predisposition to Disease
• Germ-Line Mutation
• Humans
• Middle Aged
• Nuclear Proteins
• Protein Isoforms
• Tumor Suppressor Proteins

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Authors

• Yonglan Zheng
• Jing Zhang
• Qun Niu
• Dezheng Huo
• Olufunmilayo I Olopade

Publication date

2012-02-20

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Cancer

Center for Clinical Cancer Genetics and Global Health, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA.

Release reference

Cancer. 2012 Mar;118(5):1362-70

Related books

• Books of African Americans
• Books of Breast Neoplasms
• Books of Carcinoma
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