XMRV accelerates cellular proliferation, transformational activity, and invasiveness of prostate cancer cells by downregulating p27(Kip1).

Abstract

We propose that downregulation of p27(Kip1) by XMRV infection facilitates transition of G1 to S, thereby accelerates growth of prostate cancer cells.

Our findings implicate that if XMRV is present in humans, then under appropriate cellular microenvironment it may serve as a cofactor to promote cancer progression in the prostate.

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Subjects

• Adenocarcinoma
• Cell Line, Tumor
• Cell Proliferation
• Cell Transformation, Neoplastic
• Cyclin-Dependent Kinase Inhibitor p27
• Disease Progression
• Down-Regulation
• Humans
• Male
• Metalloproteases
• MicroRNAs
• Neoplasm Invasiveness
• Prostatic Neoplasms
• RNA, Messenger
• Up-Regulation
• Xenotropic murine leukemia virus-related virus

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Authors

• Jui Pandhare-Dash
• Chinmay K Mantri
• Yuanying Gong
• Zhenbang Chen
• Chandravanu Dash

Publication date

2012-04-24

Journal

Journal topics

• Prostate

Language

Eng.

Copyright

Laboratory of Retrovirology and Epigenetics, Center for AIDS Health Disparities Research, Vanderbilt-Meharry Center For AIDS Research (CFAR), Meharry Medical College School of Medicine, 1005 Dr. DB Todd Jr Blvd., Nashville, TN 37208, USA.

Release reference

Prostate. 2012 Jun;72(8):886-97

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