Antimetastatic activity of honokiol in osteosarcoma.

Abstract

Honokiol exhibited prominent antimetastatic activity in experimental osteosarcoma and caused rapid cell death in vitro that was unrelated to necrosis, apoptosis, or autophagy.

The authors concluded that honokiol has considerable potential for the treatment of metastasizing osteosarcoma.

Full Text

• DOI - Cancer (DOI)
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Subjects

• Animals
• Antineoplastic Agents
• Apoptosis
• Biphenyl Compounds
• Bone Neoplasms
• Cell Death
• Cell Line, Tumor
• Cell Proliferation
• Drug Screening Assays, Antitumor
• Female
• Humans
• Lignans
• Liver Neoplasms
• Lung Neoplasms
• Mice
• Mice, Inbred C3H
• Osteosarcoma

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Authors

• Patrick Steinmann
• Denise K Walters
• Matthias J E Arlt
• Ingo J Banke
• Urs Ziegler
• Bettina Langsam
• Jack Arbiser
• Roman Muff
• Walter Born
• Bruno Fuchs

Publication date

2012-04-10

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Cancer

Laboratory for Orthopedic Research, Department of Orthopedics, University of Zurich, Switzerland.

Release reference

Cancer. 2012 Apr;118(8):2117-27

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