Gene expression networks in COPD: microRNA and mRNA regulation.

Abstract

miRNA and mRNA are differentially expressed in individuals with COPD compared with smokers without obstruction.

Investigating these relationships may further our understanding of the mechanisms of disease.

Full Text

• DOI - Thorax (DOI)
• Ovid Technologies, Inc. - full-text online
• Lippincott Williams & Wilkins - full-text online
• HighWire Press - full-text online
• EBSCO - full-text online

Subjects

• Aged
• Bronchi
• Cluster Analysis
• Epithelial Cells
• Female
• Gene Expression Profiling
• Gene Expression Regulation
• Gene Regulatory Networks
• Humans
• Lung
• Male
• MicroRNAs
• Middle Aged
• Oligonucleotide Array Sequence Analysis
• Pulmonary Disease, Chronic Obstructive
• RNA, Messenger
• Reverse Transcriptase Polymerase Chain Reaction
• Smad7 Protein
• Smoking
• Transforming Growth Factor beta
• Wnt Signaling Pathway

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Authors

• Michael E Ezzie
• Melissa Crawford
• Ji-Hoon Cho
• Robert Orellana
• Shile Zhang
• Richard Gelinas
• Kara Batte
• Lianbo Yu
• Gerard Nuovo
• David Galas
• Philip Diaz
• Kai Wang
• S Patrick Nana-Sinkam

Publication date

2012-01-23

Journal

Journal topics

• Thorax

Language

Eng.

Copyright

Thorax

Department of Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA.

Release reference

Thorax. 2012 Feb;67(2):122-31

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