Early, severe and bilateral loss of LTP and LTD-like plasticity in motor cortex (M1) in de novo Parkinson's disease.

Abstract

M1 plasticity defect occurs early in PD and might affect motor learning.

Acute vs. chronic dopamine replacement could have different effects on plasticity in PD or in the networks recruited by a specific plasticity induction technique.

Full Text

• DOI - (DOI)
• Swets Information Services - full-text online
• OhioLINK Electronic Journal Center - full-text online
• Elsevier Science - full-text online
• EBSCO - full-text online

Subjects

• Adult
• Antiparkinson Agents
• Dopamine Agents
• Electroencephalography
• Evoked Potentials, Motor
• Female
• Functional Laterality
• Humans
• Levodopa
• Linear Models
• Long-Term Potentiation
• Male
• Middle Aged
• Motor Cortex
• Motor Skills
• Neuronal Plasticity
• Parkinson Disease
• Rest
• Theta Rhythm
• Transcranial Magnetic Stimulation

Similar articles

• Cerebellar Sensory Processing Alterations Impact Motor Cortical Plasticity in Parkinson's Disease: Clues from Dyskinetic Patients. (2013-03-27)
• Differences in Dopaminergic Modulation to Motor Cortical Plasticity between Parkinson's Disease and Multiple System Atrophy. (2013-05-03)
• Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia. (2012-11-08)
• Modulation of effects of intermittent theta burst stimulation applied over primary motor cortex (M1) by conditioning stimulation of the opposite M1. (2009-08-03)
• Network Connectivity and Individual Responses to Brain Stimulation in the Human Motor System. (2013-02-08)
• Direct comparison of the task-dependent discharge of M1 in hand space and muscle space. (2007-02-09)
• Activity-dependent plasticity improves M1 motor representation and corticospinal tract connectivity. (2009-02-27)
• Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's disease. (2011-03-22)
• Cerebellum to motor cortex paired associative stimulation induces bidirectional STDP-like plasticity in human motor cortex. (2012-09-19)

Authors

• Asha Kishore
• Thomas Joseph
• Balu Velayudhan
• Traian Popa
• Sabine Meunier

Publication date

2012-03-06

Journal

Journal topics

• Neurophysiology

Language

Eng.

Copyright

Comprehensive Care Centre for Movement Disorders, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Kerala 695 011, India. ashakishore99 [at] gmail.com

Release reference

Clin Neurophysiol. 2012 Apr;123(4):822-8

Related books

• Books of Antiparkinson Agents
• Books of Dopamine Agents
• Books of Electroencephalography
• Books of Evoked Potentials, Motor
• Books of Functional Laterality
• Books of Levodopa
• Books of Linear Models
• Books of Long-Term Potentiation
• Books of Motor Cortex
• Books of Motor Skills
• Books of Neuronal Plasticity
• Books of Neurophysiology
• Books of Parkinson Disease
• Books of Rest
• Books of Theta Rhythm
• Books of Transcranial Magnetic Stimulation