PSA regulates androgen receptor expression in prostate cancer cells.

Abstract

PSA localizes to nuclei of androgen-stimulated PrCa cells, and controls AR mRNA and protein levels.

This regulatory loop is specific for PSA, does not involve known AR activators such as Src and AKT, and may contribute to AR signaling under conditions of increasing PSA levels in patients.

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Subjects

• Cell Line, Tumor
• Down-Regulation
• Humans
• Male
• Metribolone
• Neoplasms, Hormone-Dependent
• Phosphorylation
• Prostate-Specific Antigen
• Prostatic Neoplasms
• Proto-Oncogene Proteins pp60(c-src)
• Receptors, Androgen

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Authors

• Parmita Saxena
• Marco Trerotola
• Tao Wang
• Jing Li
• Aejaz Sayeed
• Jennifer Vanoudenhove
• Dave S Adams
• Thomas J Fitzgerald
• Dario C Altieri
• Lucia R Languino

Publication date

2012-04-24

Journal

Journal topics

• Prostate

Language

Eng.

Copyright

Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Release reference

Prostate. 2012 May;72(7):769-76

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