These results suggest that (1) reduction in tissue E-cadherin expression in patients with OPC(+) is not permanent, and (2) high numbers of CD8(+) T cells can be distributed throughout OPC(-) tissue under normal E-cadherin expression. Together, these results extend our previous studies and continue to support a role for CD8(+) T cells in host defense against OPC.
Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences, Center School of Dentistry, New Orleans, LA, USA.
Oral Dis. 2012 Mar;18(2):153-61
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