ΔFosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488.

Abstract

These data suggest that induction of ΔFosB in striatal regions has two important behavioral consequences-increased sensitivity to drug reward, and reduced sensitivity to aversion-producing a complex phenotype that shows signs of vulnerability to addiction as well as resilience to stress.

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Subjects

• 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
• Anesthetics, Local
• Animals
• Biophysics
• Cocaine
• Conditioning, Operant
• Corpus Striatum
• Dose-Response Relationship, Drug
• Gene Expression Regulation
• Hypothalamic Area, Lateral
• Male
• Medial Forebrain Bundle
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Phosphopyruvate Hydratase
• Proto-Oncogene Proteins c-fos
• Receptors, Opioid, kappa
• Reward
• Self Stimulation

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Authors

• John W Muschamp
• Christina L Nemeth
• Alfred J Robison
• Eric J Nestler
• William A Carlezon

Publication date

2011-12-05

Journal

Journal topics

• Psychiatry
• Psychopharmacology
• Psychophysiology

Language

Eng.

Copyright

Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

Release reference

Biol Psychiatry. 2012 Jan;71(1):44-50

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