This study aimed to compare the caspofungin immunomodulating activities against Candida albicans on polymorphonuclear cells (PMNs) from renal transplant recipients (RTRs) and healthy subjects (HSs). RTR PMNs showed a significantly reduced fungicidal activity compared with that of HS PMNs. Addition of caspofungin to RTR PMNs significantly potentiated the yeast intracellular killing rate, achieving values similar to those observed for HS PMNs. These data show that caspofungin is suitable for invasive candidiasis treatment in patients with immune system-impaired components.
Antimicrobial agents and chemotherapy
Department of Public Health and Microbiology, Microbiology Section, University of Turin, Via Santena 9, 10126 Turin, Italy.
Antimicrob Agents Chemother. 2011 Dec;55(12):5936-8
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