Our studies identify a novel mechanism by which αvβ3 mitigates increased vascular leak, a pathophysiologic function central to sepsis and ALI. These studies suggest that drugs designed to block αvβ3 may have the unexpected side effect of intensifying sepsis- and ALI-associated vascular endothelial leak.
American journal of respiratory and critical care medicine
Lung Biology Center, University of California San Francisco, San Francisco, CA 94121, USA. george.su [at] ucsf.edu
Am J Respir Crit Care Med. 2012 Jan;185(1):58-66
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