Phase I safety and pharmacokinetic study of bavituximab, a chimeric phosphatidylserine-targeting monoclonal antibody, in patients with advanced solid tumors.

Abstract

Bavituximab was well tolerated at doses ranging up to 3 mg/kg weekly.

Pharmacokinetic studies support a weekly dosing regimen.

Additional phase I and II clinical trials are in progress to investigate bavituximab in combination with chemotherapy and other molecularly targeted agents.

Full Text

• DOI - Clinical cancer research : an official journal of the American Association for Cancer Research (DOI)
• HighWire Press - full-text online

Subjects

• Adult
• Aged
• Aged, 80 and over
• Antibodies, Monoclonal
• Blood Coagulation
• Blood Platelets
• Dose-Response Relationship, Drug
• Female
• Humans
• Male
• Middle Aged
• Neoplasms
• Phosphatidylserines

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Authors

• David E Gerber
• Alison T Stopeck
• Lucas Wong
• Lee S Rosen
• Philip E Thorpe
• Joseph S Shan
• Nuhad K Ibrahim

Publication date

2011-11-02

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Clinical cancer research : an official journal of the American Association for Cancer Research

Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Release reference

Clin Cancer Res. 2011 Nov;17(21):6888-96

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