The clinical implications and biologic relevance of neurofilament expression in gastroenteropancreatic neuroendocrine neoplasms.

Abstract

INA is a novel NEN biomarker, and its expression was associated with MAPK signaling and proliferation.

In clinical samples, elevated INA was correlated with Ki-67 and identified malignancy. INA may provide additional biologic information relevant to delineation of both pancreatic NEN tumor phenotypes and clinical behavior.

Full Text

• DOI - Cancer (DOI)
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Subjects

• Animals
• Cell Line, Tumor
• Gastrointestinal Neoplasms
• Humans
• Intermediate Filament Proteins
• Mice
• Neuroendocrine Tumors
• Neurofilament Proteins
• Pancreas
• Pancreatic Neoplasms
• Tumor Markers, Biological

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Authors

• Simon Schimmack
• Ben Lawrence
• Bernhard Svejda
• Daniele Alaimo
• Hubertus Schmitz-Winnenthal
• Lars Fischer
• Markus W Büchler
• Mark Kidd
• Irvin Modlin

Publication date

2012-05-04

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Cancer

Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT, USA.

Release reference

Cancer. 2012 May;118(10):2763-75

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