Challenging the feasibility and clinical significance of current guidelines on lymph node examination in rectal cancer in the era of neoadjuvant therapy.

Abstract

In a tertiary cancer center, the 12-LN threshold was not relevant and often not achievable in patients with RC treated with neoadjuvant therapy.

Lower LN count after neoadjuvant treatment was not associated with understaging or inferior survival.

Although we support the critical importance of careful pathologic examination and adequate nodal staging, we challenge the relevance of LN count both in clinical practice and as a quality indicator in RC.

Full Text

• DOI - Journal of clinical oncology : official journal of the American Society of Clinical Oncology (DOI)
• HighWire Press - full-text online
• EBSCO - full-text online

Subjects

• Feasibility Studies
• Female
• Humans
• Lymph Nodes
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Staging
• Practice Guidelines as Topic
• Rectal Neoplasms

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Authors

• Anand Govindarajan
• Mithat Gönen
• Martin R Weiser
• Jinru Shia
• Larissa K Temple
• Jose G Guillem
• Philip B Paty
• Garrett M Nash

Publication date

2011-11-30

Journal

Journal topics

• Medical Oncology

Language

Eng.

Copyright

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Release reference

J Clin Oncol. 2011 Dec;29(34):4568-73

Related books

• Books of Feasibility Studies
• Books of Lymph Nodes
• Books of Lymphatic Metastasis
• Books of Medical Oncology
• Books of Neoadjuvant Therapy
• Books of Neoplasm Staging
• Books of Practice Guidelines as Topic
• Books of Rectal Neoplasms