This study demonstrates that iNPH affects corticospinal excitability, causing disinhibition of the motor cortex.
Recovery of corticospinal excitability following ventricular shunt placement is correlated with clinical improvement.
These findings support the view that reduced control of motor output, rather than impairment of central motor conduction, is responsible for gait disturbances in patients with iNPH.
2012-02-02
Eng.
Department of Neurosurgery, Rambam Health Care Campus, and B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. a_chistyakov [at] rambam.health.gov.il
J Neurosurg. 2012 Feb;116(2):453-9
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