Predictive factors for BRCA1/BRCA2 mutations in women with ductal carcinoma in situ.

Abstract

Women who had DCIS and a family history of OC or who had BRCAPRO scores ≥10% had a high rate of BRCA positivity regardless of age at diagnosis.

These findings suggest that high-risk patients with DCIS are appropriate candidates for genetic testing for BRCA mutations in the presence of predictive factors even if they do not have invasive breast cancer.

Full Text

• DOI - Cancer (DOI)
• John Wiley & Sons, Inc. - full-text online
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Subjects

• Adult
• Breast Neoplasms
• Carcinoma, Intraductal, Noninfiltrating
• Female
• Genes, BRCA1
• Genes, BRCA2
• Humans
• Logistic Models
• Middle Aged
• Mutation
• Predictive Value of Tests

Similar articles

• Ductal carcinoma in situ in BRCA mutation carriers. (2007-02-19)
• BRCA mutations in women with ductal carcinoma in situ. (2007-07-19)
• Is mammographic breast density a breast cancer risk factor in women with BRCA mutations? (2010-08-09)
• Baseline E(2) levels are higher in BRCA2 mutation carriers: a potential target for prevention? (2012-12-28)
• Association between clinical characteristics and risk-reduction interventions in women who underwent BRCA1 and BRCA2 testing: a single-institution study. (2006-12-18)
• [MRI outstands mammogram in sensitivity of breast ductal carcinoma in situ:an analysis of 122 cases]. (2013-04-12)
• Early Onset Breast Cancer in a Registry-based Sample of African-American Women: BRCA Mutation Prevalence, and Other Personal and System-level Clinical Characteristics. (2013-01-16)
• Dealing with the unexpected: consumer responses to direct-access BRCA mutation testing. (2013-02-12)
• Impact of family history on choosing risk-reducing surgery among BRCA mutation carriers. (2013-01-17)

Authors

• Soley Bayraktar
• Nisreen Elsayegh
• Angelica M Gutierrez Barrera
• Heather Lin
• Henry Kuerer
• Tunc Tasbas
• Kimberly I Muse
• Kaylene Ready
• Jennifer Litton
• Funda Meric-Bernstam
• Gabriel N Hortobagyi
• Constance T Albarracin
• Banu Arun

Publication date

2012-03-05

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Cancer

Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

Release reference

Cancer. 2012 Mar;118(6):1515-22

Related books

• Books of Breast Neoplasms
• Books of Carcinoma, Intraductal, Noninfiltrating
• Books of Genes, BRCA1
• Books of Genes, BRCA2
• Books of Logistic Models
• Books of Mutation
• Books of Neoplasms
• Books of Predictive Value of Tests