Validation of 24-hour flucytosine MIC determination by comparison with 48-hour determination by the Clinical and Laboratory Standards Institute M27-A3 broth microdilution reference method.

Abstract

Flucytosine and itraconazole are the only antifungal agents for which the Clinical Laboratory and Standards Institute recommendations include MIC breakpoint readings at 48 h only.

Here we show good essential and categorical agreement between the flucytosine MIC readings at 48 and 24 h for Candida species.

Full Text

• DOI - Journal of clinical microbiology (DOI)
• HighWire Press - full-text online
• EBSCO - full-text online

Subjects

• Antifungal Agents
• Candida
• Flucytosine
• Humans
• Itraconazole
• Microbial Sensitivity Tests
• Time Factors

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Authors

• Shawn R Lockhart
• Carol B Bolden
• Naureen Iqbal
• Randall J Kuykendall

Publication date

2011-11-29

Journal

Journal topics

• Microbiology

Language

Eng.

Copyright

Journal of clinical microbiology

Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop G-11, Atlanta, GA 30333, USA. gyi2 [at] cdc.gov

Release reference

J Clin Microbiol. 2011 Dec;49(12):4322-5

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