The use of NIPPV has increased significantly over time among patients hospitalized for acute exacerbations of COPD, whereas the need for intubation and in-hospital mortality has declined. However, the rising mortality rate in a small but expanding group of patients requiring invasive mechanical ventilation after treatment with noninvasive ventilation needs further investigation.
American journal of respiratory and critical care medicine
University of Pittsburgh, Pennsylvania, USA.
Am J Respir Crit Care Med. 2012 Jan;185(2):152-9
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