Micromanaging the classification of colon cancer: the role of the microRNAome.

Abstract

Recent advances in our understanding of the microRNAome (miRNAome) have provided further insights into the molecular pathogenesis of colorectal cancer and shown a potential role for miRNAs in distinguishing molecular subtypes.

The mucosa-adenoma-carcinoma model can now integrate miRNAs into the known genetic alterations that drive the progression of colorectal neoplasia.

Full Text

• DOI - Clinical cancer research : an official journal of the American Association for Cancer Research (DOI)
• HighWire Press - full-text online

Subjects

• Adenocarcinoma
• Adenoma
• Colorectal Neoplasms
• Humans
• MicroRNAs
• Microsatellite Instability
• Microsatellite Repeats
• Protein Array Analysis

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Authors

• Eduardo Vilar
• Josep Tabernero
• Stephen B Gruber

Publication date

2011-12-02

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Clinical cancer research : an official journal of the American Association for Cancer Research

Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA. evilar [at] umich.edu

Release reference

Clin Cancer Res. 2011 Dec;17(23):7207-9

Related books

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