Prognostic significance of alterations in IDH enzyme isoforms in patients with AML treated with high-dose cytarabine and idarubicin.

Abstract

IDH aberrations and IDH1 codon 105 SNP occur in about 30% of younger patients with AML, mostly with diploid karyotype.

Using high-dose ara-C-based induction regimens, we did not detect an association with outcome for any of the aberrations.

Full Text

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Subjects

• Adolescent
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols
• Cytarabine
• Humans
• Idarubicin
• Isocitrate Dehydrogenase
• Leukemia, Myeloid, Acute
• Middle Aged
• Mutation
• Polymorphism, Single Nucleotide
• Prognosis

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Authors

• Farhad Ravandi
• Keyur Patel
• Rajyalakshmi Luthra
• Stefan Faderl
• Marina Konopleva
• Tapan Kadia
• Mark Brandt
• Sherry Pierce
• Steven Kornblau
• Michael Andreeff
• Xuemei Wang
• Guillermo Garcia-Manero
• Jorge Cortes
• Hagop Kantarjian

Publication date

2012-05-04

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

Cancer

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. fravandi [at] mdanderson.org

Release reference

Cancer. 2012 May;118(10):2665-73

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