Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts.

Abstract

Our work provided a comprehensive set of methods to analyze mouse cardiac transcriptome complexity at individual exon and transcript levels.

Applications of the methods may infer important new insights to gene regulation in normal and disease hearts in terms of exon utilization and potential involvement of novel components of cardiac transcriptome.

Full Text

• DOI - Circulation research (DOI)
• Swets Information Services - full-text online
• Ovid Technologies, Inc. - full-text online
• Lippincott Williams & Wilkins - full-text online
• HighWire Press - full-text online

Subjects

• Animals
• Disease Models, Animal
• Exons
• Gene Expression Profiling
• Gene Expression Regulation
• Heart
• Heart Failure
• High-Throughput Nucleotide Sequencing
• Male
• Mice
• Mice, Inbred C57BL
• Molecular Sequence Data
• Sequence Analysis, RNA
• Transcription, Genetic

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Authors

• Jae-Hyung Lee
• Chen Gao
• Guangdun Peng
• Christopher Greer
• Shuxun Ren
• Yibin Wang
• Xinshu Xiao

Publication date

2011-12-13

Journal

Journal topics

• Cardiovascular System

Language

Eng.

Copyright

Circulation research

Integrative Biology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Release reference

Circ Res. 2011 Dec;109(12):1332-41

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