Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells.

Abstract

B. infantis administration to humans selectively promotes immunoregulatory responses, suggesting that this microbe may have therapeutic utility in patients with inflammatory disease. Cross-talk between multiple pattern-recognition receptors and metabolic pathways determines the innate and subsequent T regulatory cell response to B. infantis.

These findings link nutrition, microbiota and the induction of tolerance within the gastrointestinal mucosa.

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Subjects

• Adult
• Bifidobacterium
• Cell Communication
• Cells, Cultured
• Coculture Techniques
• Cytokines
• Dendritic Cells
• Double-Blind Method
• Forkhead Transcription Factors
• Humans
• Interleukin-10
• Metabolic Networks and Pathways
• Probiotics
• Receptors, Pattern Recognition
• T-Lymphocytes, Regulatory
• Tretinoin

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Authors

• Patrycja Konieczna
• David Groeger
• Mario Ziegler
• Remo Frei
• Ruth Ferstl
• Fergus Shanahan
• Eamonn M M Quigley
• Barry Kiely
• Cezmi A Akdis
• Liam O'Mahony

Publication date

2012-02-06

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Zurich, Switzerland.

Release reference

Gut. 2012 Mar;61(3):354-66

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