Decrease in donor heart injury by recombinant clusterin protein in cold preservation with University of Wisconsin solution.

Abstract

Our data suggest that supplement of CLU protein in a cold preservation solution may have potential in improving cold preservation of donor organs in transplantation.

Full Text

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Subjects

• Adenosine
• Allopurinol
• Animals
• Cardiotonic Agents
• Cell Membrane
• Clusterin
• Cold Ischemia
• Glutathione
• Graft Survival
• Heart Transplantation
• Human Umbilical Vein Endothelial Cells
• Humans
• Insulin
• L-Lactate Dehydrogenase
• Male
• Membrane Fluidity
• Mice
• Mice, Inbred C57BL
• Myocardium
• Neutrophil Infiltration
• Organ Preservation
• Organ Preservation Solutions
• Raffinose
• Recombinant Proteins

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Authors

• Qiunong Guan
• Shuyuan Li
• Gordon Yip
• Martin E Gleave
• Christopher Y C Nguan
• Caigan Du

Publication date

2012-02-14

Journal

Journal topics

• General Surgery

Language

Eng.

Copyright

Surgery

Department of Urologic Sciences, University of British Columbia, Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, and the Vancouver Prostate Centre, Vancouver, BC, Canada.

Release reference

Surgery. 2012 Mar;151(3):364-71

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