Potential responders to FOLFOX therapy for colorectal cancer by Random Forests analysis.

Abstract

Random Forests on gene-expression data for CRC patients was effectively able to stratify responders to FOLFOX therapy with high accuracy, and use of pharmacogenomics in anticancer therapy is the first step in planning personalised therapy.

Full Text

• DOI - British journal of cancer (DOI)
• Swets Information Services - full-text online
• Nature Publishing Group - full-text online
• EBSCO - full-text online

Subjects

• Antineoplastic Combined Chemotherapy Protocols
• Colorectal Neoplasms
• Fluorouracil
• Humans
• Leucovorin
• Models, Theoretical
• Oligonucleotide Array Sequence Analysis
• Organoplatinum Compounds
• Survival Analysis

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Authors

• S Tsuji
• Y Midorikawa
• T Takahashi
• K Yagi
• T Takayama
• K Yoshida
• Y Sugiyama
• H Aburatani

Publication date

2012-01-04

Journal

Journal topics

• Neoplasms

Language

Eng.

Copyright

British journal of cancer

Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.

Release reference

Br J Cancer. 2012 Jan;106(1):126-32

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