The decrease in sulphotransferase activity provides an explanation for mucin hyposulphation observed in the LSGs from SS patients.
The decrease in Gal3STs activity was not a consequence of reduced gene expression, but probably due to alterations in the enzyme activity regulation. Interestingly, the levels of sulphotransferase activity detected correlated well with secretory function, inflammation and serology. Finally, we postulate that pro-inflammatory cytokines induced by autoantibodies, such as Ro/SS-A and La/SS-B in SS patients, may modulate Gal3ST activity, thereby altering mucin quality and leading to mouth dryness.
2012-02-20
Eng.
Rheumatology (Oxford, England)
Institute of Biomedical Sciences, University of Chile, Casilla, Chile.
Rheumatology (Oxford). 2012 Mar;51(3):482-90
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