Regression of cardiac hypertrophy by granulocyte colony-stimulating factor-stimulated interleukin-1β synthesis.

Abstract

Granulocyte colony-stimulating factor treatment improves the cardiac function and leads to the regression of myocardial fibrosis after pressure unloading.

These findings reveal a previously unknown mechanism of fibrosis regression.

Granulocyte colony-stimulating factor might be a potential pharmacological treatment approach for patients suffering from congestive heart failure after aortic valve replacement, although further basic research and clinical trials are required in order to prove beneficial effects of G-CSF in the human organism.

Full Text

• DOI - European heart journal (DOI)
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Subjects

• Animals
• Aorta
• Aortic Valve Stenosis
• Bone Marrow Cells
• Cell Transdifferentiation
• Constriction
• Female
• Fibrosis
• Granulocyte Colony-Stimulating Factor
• Hypertrophy, Left Ventricular
• Interleukin-1beta
• Mice
• Mice, Inbred C57BL
• Myocardium
• Stroke Volume
• Up-Regulation
• Ventricular Remodeling

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Authors

• Sebastian Szardien
• Holger M Nef
• Sandra Voss
• Christian Troidl
• Christoph Liebetrau
• Jedrzej Hoffmann
• Maximilian Rauch
• Katharina Mayer
• Kathrin Kimmich
• Andreas Rolf
• Johannes Rixe
• Kerstin Troidl
• Baktybek Kojonazarov
• Ralph T Schermuly
• Sawa Kostin
• Albrecht Elsäss

Publication date

2012-03-02

Journal

Journal topics

• Cardiology

Language

Eng.

Copyright

European heart journal

Department of Cardiology, Kerckhoff Heart and Thorax Center, Benekestrasse 2-8, D-61231 Bad Nauheim, Germany.

Release reference

Eur Heart J. 2012 Mar;33(5):595-605

Related books

• Books of Animals
• Books of Aorta
• Books of Aortic Valve Stenosis
• Books of Bone Marrow Cells
• Books of Cardiology
• Books of Cell Transdifferentiation
• Books of Constriction
• Books of Fibrosis
• Books of Granulocyte Colony-Stimulating Factor
• Books of Hypertrophy, Left Ventricular
• Books of Interleukin-1beta
• Books of Mice
• Books of Mice, Inbred C57BL
• Books of Myocardium
• Books of Stroke Volume
• Books of Up-Regulation
• Books of Ventricular Remodeling