4-hydroxy-2-nonenal mediates genotoxicity and bystander effects caused by Enterococcus faecalis-infected macrophages.

Abstract

4-HNE can act as an autochthonous mitotic spindle poison in normal colonic epithelial and colon cancer cells.

This finding links the macrophage-induced bystander effects to colorectal carcinogenesis.

Full Text

• DOI - Gastroenterology (DOI)
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Subjects

• Aldehydes
• Animals
• Autocrine Communication
• Biopsy
• Bystander Effect
• Coculture Techniques
• Colon
• Colorectal Neoplasms
• DNA Damage
• Disease Models, Animal
• Enterococcus faecalis
• Epithelial Cells
• G2 Phase Cell Cycle Checkpoints
• Glutathione Transferase
• Gram-Positive Bacterial Infections
• HCT116 Cells
• Histones
• Humans
• Interleukin-10
• Macrophages
• Mice
• Mice, Knockout
• Mitotic Spindle Apparatus
• RNA Interference
• Stathmin
• Tetraploidy
• Time Factors
• Transfection

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Authors

• Xingmin Wang
• Yonghong Yang
• Danny R Moore
• Susan L Nimmo
• Stanley A Lightfoot
• Mark M Huycke

Publication date

2012-02-27

Journal

Journal topics

• Gastroenterology

Language

Eng.

Copyright

Gastroenterology

The Muchmore Laboratories for Infectious Diseases Research, Research Service, Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma 73104, USA.

Release reference

Gastroenterology. 2012 Mar;142(3):543-551.e7

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