Glucose-dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors.

Abstract

The numerous GIP receptors in gastroenteropancreatic and bronchial NET represent novel universal molecular targets for clinical applications, in particular for in vivo scintigraphy and targeted radiotherapy.

These results may also be the basis for multiple targeting, with concomitant use of GIP, somatostatin, and GLP-1 analogs as radiotracers.

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Subjects

• Bronchial Neoplasms
• Gastric Inhibitory Polypeptide
• Gastrointestinal Neoplasms
• Gastrointestinal Tract
• Gene Expression Regulation, Neoplastic
• Humans
• Iodine Radioisotopes
• Neuroendocrine Tumors
• Osmolar Concentration
• Pancreatic Neoplasms
• Peptide Fragments
• Receptors, Gastrointestinal Hormone
• Receptors, Glucagon
• Tissue Distribution

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Authors

• Beatrice Waser
• Ruth Rehmann
• Claire Sanchez
• Daniel Fourmy
• Jean Claude Reubi

Publication date

2012-02-07

Journal

Journal topics

• Endocrinology
• Metabolism

Language

Eng.

Copyright

Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, CH-3010 Berne, Switzerland.

Release reference

J Clin Endocrinol Metab. 2012 Feb;97(2):482-8

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