A mechanistic role for type III IFN-λ1 in asthma exacerbations mediated by human rhinoviruses.

Abstract

Our findings suggest that HRV infections in children with asthma are specifically associated with acute wheezing, and that type III IFN-λ(1) responses mediate exacerbations caused by HRV. Modulation of IFN- λ(1) should be studied as a therapeutic target for exacerbations caused by HRV.

Full Text

• DOI - American journal of respiratory and critical care medicine (DOI)
• ProQuest Information and Learning - full-text online
• HighWire Press - full-text online

Subjects

• Adolescent
• Asthma
• Child
• Child, Preschool
• Female
• Humans
• Interleukin-6
• Interleukins
• Male
• Picornaviridae Infections
• Prospective Studies
• Respiratory Sounds
• Rhinovirus
• Severity of Illness Index
• Viral Load

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Authors

• E Kathryn Miller
• Johanna Zea Hernandez
• Vera Wimmenauer
• Bryan E Shepherd
• Diego Hijano
• Romina Libster
• M Elina Serra
• Niranjan Bhat
• Juan P Batalle
• Yassir Mohamed
• Andrea Reynaldi
• Andrea Rodriguez
• Monica Otello
• Nestor Pisapia
• Jimena Bugna
• Miguel Bellabarba
• Davi

Publication date

2012-03-02

Journal

Journal topics

• Critical Care
• Respiratory Tract Diseases

Language

Eng.

Copyright

American journal of respiratory and critical care medicine

Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.

Release reference

Am J Respir Crit Care Med. 2012 Mar;185(5):508-16

Related books

• Books of Asthma
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• Books of Prospective Studies
• Books of Respiratory Sounds
• Books of Respiratory Tract Diseases
• Books of Rhinovirus
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