Cystic fibrosis transmembrane conductance regulator regulates epithelial cell response to Aspergillus and resultant pulmonary inflammation.

Abstract

Data demonstrate a critical role for CFTR in mediating EC responses to A. fumigatus.

Results suggest that the fungus elicits aberrant pulmonary inflammation in the setting of CFTR mutation, supporting the potential role of antifungals to halt progressive CF lung disease.

Full Text

• DOI - American journal of respiratory and critical care medicine (DOI)
• ProQuest Information and Learning - full-text online
• HighWire Press - full-text online

Subjects

• Animals
• Apoptosis
• Aspergillosis
• Aspergillus fumigatus
• Bronchi
• Cell Line
• Cystic Fibrosis
• Cystic Fibrosis Transmembrane Conductance Regulator
• Cytokines
• Epithelial Cells
• Flow Cytometry
• Host-Pathogen Interactions
• Immunity, Cellular
• Inflammation
• Lung
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Respiratory Mucosa
• Trachea

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Authors

• Neelkamal Chaudhary
• Kausik Datta
• Frederic B Askin
• Janet F Staab
• Kieren A Marr

Publication date

2012-02-02

Journal

Journal topics

• Critical Care
• Respiratory Tract Diseases

Language

Eng.

Copyright

American journal of respiratory and critical care medicine

Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.

Release reference

Am J Respir Crit Care Med. 2012 Feb;185(3):301-10

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