Antibiotic-resistant Staphylococcus aureus is of great concern, as it causes a wide range of life-threatening infections.
The current study demonstrates that dihydropyrrolone (DHP)-coated polyacrylamide substrates are effective in reducing the number of culturable clinical isolates of S. aureus in vitro in a dose-dependent manner and are able to reduce the pathogenic potential of staphylococcal infection in a subcutaneous infection model.
Covalently bound DHPs therefore show great potential for use as an antimicrobial strategy in device-related applications.
2012-01-23
Eng.
Antimicrobial agents and chemotherapy
School of Chemistry, University of New South Wales, Sydney, NSW, Australia.
Antimicrob Agents Chemother. 2012 Feb;56(2):1138-41
© Galenicom 1999-2013