In the perioperative period, the concentration changes of the 4 spinal neurotransmitters have a distinct time course. CSF substance P seems to increase very rapidly with surgical intervention, whereas the CSF norepinephrine concentration tends to decrease.
At clinical doses, pregabalin does not seem to modulate these spinal neurotransmitter concentrations.
2012-01-23
Eng.
Anesthesia and analgesia
Department of Anesthesiology, Rush University Medical Center, Chicago, IL 60612, USA. asokumar [at] aol.com
Anesth Analg. 2012 Feb;114(2):434-41
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