The prevalence of gastroesophageal reflux disease in children with chronic otitis media with effusion/recurrent acute otitis media may be higher than the overall prevalence for children.
Presence of pepsin/pepsinogen in the middle ear could be related to physiologic reflux. A cause-effect relationship between pepsin/pepsinogen in the middle ear and otitis media is unclear.
Antireflux therapy for otitis media cannot be endorsed based on existing research.
2012-03-02
Eng.
Universidade Federal de Ciencias da Saude de Porto Alegre, Brazil. mmiura.voy [at] terra.com.br
Otolaryngol Head Neck Surg. 2012 Mar;146(3):345-52
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