Overdosage with hydroxychloroquine seemed a significant risk factor for toxicity.
Different individuals were more or less sensitive to different tests.
Fields can be sensitive but only if read with a low threshold for change.
Hydroxychloroquine causes early parafoveal loss of the outer segment lines on SD-OCT, with the first changes often evident in the inferotemporal quadrant.
Parafoveal thinning of the outer nuclear layer follows, before retinal pigment epithelium damage is visible.
Careful screening with multiple tests can detect toxic damage before prominent loss of the outer nuclear layer.
2012-04-11
Eng.
Department of Ophthalmology, Stanford University School of Medicine, Byers Eye Institute at Stanford, 2452 Watson Ct, Palo Alto, CA 94303-5353, USA. marmor [at] stanford.edu
Arch Ophthalmol. 2012 Apr;130(4):461-9
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