Prognostic effect of circulating adiponectin in a randomized 2 x 2 trial of low-dose tamoxifen and fenretinide in premenopausal women at risk for breast cancer.

Abstract

Low adiponectin levels are associated with a history of prior intraepithelial neoplasia or pT1mic/pT1a breast cancer and higher risk of second breast neoplastic events in premenopausal women.

The associations are independent of BMI, mammographic density, and treatment.

Our findings support the role of adiponectin as a potential target for premenopausal breast cancer prevention and treatment.

Full Text

• DOI - Journal of clinical oncology : official journal of the American Society of Clinical Oncology (DOI)
• HighWire Press - full-text online
• EBSCO - full-text online

Subjects

• Adiponectin
• Anticarcinogenic Agents
• Breast Neoplasms
• Double-Blind Method
• Female
• Fenretinide
• Humans
• Leptin
• Middle Aged
• Premenopause
• Prognosis
• Risk Factors
• Tamoxifen

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Authors

• Debora Macis
• Sara Gandini
• Aliana Guerrieri-Gonzaga
• Harriet Johansson
• Paolo Magni
• Massimiliano Ruscica
• Matteo Lazzeroni
• Davide Serrano
• Massimiliano Cazzaniga
• Serena Mora
• Irene Feroce
• Maria Pizzamiglio
• Maria Teresa Sandri
• Marcella Gulisano
• Bernardo Bonanni

Publication date

2012-01-09

Journal

Journal topics

• Medical Oncology

Language

Eng.

Copyright

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Medical Oncology Unit, E.O. Ospedali Galliera, Mura delle Cappuccine 14, 16128 Genoa, Italy.

Release reference

J Clin Oncol. 2012 Jan;30(2):151-7

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