Total and undercarboxylated osteocalcin predict changes in insulin sensitivity and β cell function in elderly men at high cardiovascular risk.

Abstract

Changes in serum osteocalcin and ucOC are associated with an improvement in insulin secretion and sensitivity, which suggests a possible role of bone in the development of type 2 diabetes.

This trial is registered at clinicaltrials.gov as ISRCTN35739639.

Full Text

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Subjects

• Aged
• Biological Markers
• Blood Glucose
• Cardiovascular Diseases
• Cross-Sectional Studies
• Humans
• Insulin
• Insulin Resistance
• Insulin-Secreting Cells
• Linear Models
• Longitudinal Studies
• Male
• Multivariate Analysis
• Osteocalcin
• Risk Factors

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Authors

• Mònica Bulló
• José Maria Moreno-Navarrete
• José Manuel Fernández-Real
• Jordi Salas-Salvadó

Publication date

2011-12-22

Journal

Journal topics

• Nutritional Physiological Phenomena

Language

Eng.

Copyright

Human Nutrition Unit, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain. monica.bullo [at] urv.cat

Release reference

Am J Clin Nutr. 2012 Jan;95(1):249-55

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• Books of Insulin Resistance
• Books of Insulin-Secreting Cells
• Books of Linear Models
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