Children with severe TBI are infrequent at any one hospital in the United States, and few hospitals treat large numbers of children with severe TBI. To effectively plan trials of therapies for severe TBI, much attention has to be paid to selecting the right types of centers to maximize enrollment efficiency.
Department of Emergency Medicine, University of Michigan, Ann Arbor MI 48105, USA. stanleyr [at] umich.edu
Pediatrics. 2012 Jan;129(1):e24-30
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