Our data show that the emergence of CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with more aggressive clinical disease. Importantly, these findings were independent of tumor cell prognostic markers and could not be accounted for by patient age, changes in regulatory T-cell frequency, or cytomegalovirus serostatus (n = 217).
Clinical cancer research : an official journal of the American Association for Cancer Research
Department of Infection, Cardiff University, Wales, UK.
Clin Cancer Res. 2012 Feb;18(3):678-87
© Galenicom 1999-2013