Morphological and biomechanical remodeling of the hepatic portal vein in a swine model of portal hypertension.

Abstract

Our study suggests that the morphological and biomechanical properties of swine hepatic portal veins change significantly during the PHT process, which may play a critical role in the development of PHT and serve as potential therapeutic targets during clinical practice.

Full Text

• DOI - Annals of vascular surgery (DOI)
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Subjects

• Animals
• Biomechanics
• Carbon Tetrachloride
• Compliance
• Down-Regulation
• Elastic Modulus
• Female
• Gene Expression Regulation, Enzymologic
• Hypertension, Portal
• Liver Cirrhosis, Experimental
• Male
• Nitric Oxide Synthase Type III
• Pentobarbital
• Portal Pressure
• Portal Vein
• RNA, Messenger
• Swine
• Time Factors

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Authors

• Xi-Ju He
• Tie-Zhu Huang
• Pei-Jun Wang
• Xing-Chun Peng
• Wen-Chun Li
• Jun Wang
• Jie Tang
• Na Feng
• Ming-Hua Yu

Publication date

2012-02-06

Journal

Journal topics

• Vascular Surgical Procedures

Language

Eng.

Copyright

Annals of vascular surgery

Laboratory of Biomechanics, Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.

Release reference

Ann Vasc Surg. 2012 Feb;26(2):259-67

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