Surfactant protein-D regulates effector cell function and fibrotic lung remodeling in response to bleomycin injury.

Abstract

These data suggest that alveolar SP-D regulates numbers of macrophages and fibrocytes in the lungs, profibrotic cytokine expression, and fibrotic lung remodeling in response to BLM injury.

Full Text

• DOI - American journal of respiratory and critical care medicine (DOI)
• ProQuest Information and Learning - full-text online
• HighWire Press - full-text online

Subjects

• Acute Lung Injury
• Airway Remodeling
• Animals
• Bleomycin
• Bronchoalveolar Lavage Fluid
• Cytokines
• Disease Models, Animal
• Idiopathic Pulmonary Fibrosis
• Lung
• Macrophages
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Mice, Transgenic
• Pulmonary Surfactant-Associated Protein A
• Pulmonary Surfactant-Associated Protein D
• Rats

Similar articles

• Profibrotic Activities for Matrix Metalloproteinase-8 during Bleomycin-Mediated Lung Injury. (2013-03-13)
• Role of urokinase plasminogen activator receptor-associated protein in mouse lung. (2012-02-07)
• Amphiregulin-dependent mucous cell metaplasia in a model of nonallergic lung injury. (2012-09-03)
• Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. (2008-06-27)
• Role of focal adhesion kinase in lung remodeling of endotoxemic rats. (2012-04-17)
• A role for hyaluronan in macrophage accumulation and collagen deposition after bleomycin-induced lung injury. (2000-11-03)
• Animal Models of Fibrotic Lung Disease. (2013-03-22)
• Fibrotic response of tissue remodeling in COPD. (2011-03-22)
• Endoplasmic reticulum stress as a pro-fibrotic stimulus. (2012-11-28)

Authors

• Yoshinori Aono
• Julie G Ledford
• Sambuddho Mukherjee
• Hirohisa Ogawa
• Yasuhiko Nishioka
• Saburo Sone
• Michael F Beers
• Paul W Noble
• Jo Rae Wright

Publication date

2012-03-02

Journal

Journal topics

• Critical Care
• Respiratory Tract Diseases

Language

Eng.

Copyright

American journal of respiratory and critical care medicine

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA.

Release reference

Am J Respir Crit Care Med. 2012 Mar;185(5):525-36

Related books

• Books of Acute Lung Injury
• Books of Airway Remodeling
• Books of Animals
• Books of Bleomycin
• Books of Bronchoalveolar Lavage Fluid
• Books of Critical Care
• Books of Cytokines
• Books of Disease Models, Animal
• Books of Idiopathic Pulmonary Fibrosis
• Books of Lung
• Books of Macrophages
• Books of Mice
• Books of Mice, Inbred C57BL
• Books of Mice, Knockout
• Books of Mice, Transgenic
• Books of Pulmonary Surfactant-Associated Protein A
• Books of Pulmonary Surfactant-Associated Protein D
• Books of Rats
• Books of Respiratory Tract Diseases