Mitochondrial oxidative stress in aortic stiffening with age: the role of smooth muscle cell function.

Abstract

Mitochondrial oxidative stress over a lifetime causes aortic stiffening, in part by inducing vascular wall remodeling, intrinsic changes in SMC stiffness, and aortic SMC apoptosis.

Full Text

• DOI - Arteriosclerosis, thrombosis, and vascular biology (DOI)
• Swets Information Services - full-text online
• Ovid Technologies, Inc. - full-text online
• Lippincott Williams & Wilkins - full-text online
• HighWire Press - full-text online

Subjects

• Actins
• Age Factors
• Aging
• Animals
• Aorta
• Aortic Diseases
• Apoptosis
• Cells, Cultured
• Collagen Type I
• Compliance
• Disease Models, Animal
• Elastin
• Forkhead Transcription Factors
• Genotype
• Hydrogen Peroxide
• Insulin-Like Growth Factor I
• Matrix Metalloproteinase 2
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Mitochondria
• Mitogen-Activated Protein Kinase 8
• Muscle, Smooth, Vascular
• Myocytes, Smooth Muscle
• NADPH Oxidase
• Oxidative Stress
• Phenotype
• Proto-Oncogene Proteins c-akt
• Pulsatile Flow
• Stroke Volume
• Superoxide Dismutase
• Superoxides
• Transfection
• Ultrasonography, Doppler, Pulsed
• Vasodilation
• Ventricular Function, Left
• Ventricular Pressure

Similar articles

• Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. (2007-02-15)
• Inflammation and oxidative stress are associated differently with endothelial function and arterial stiffness in healthy subjects and in patients with atherosclerosis. (2008-07-08)
• Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2. (2005-06-20)
• Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction. (2008-02-29)
• Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat. (2010-10-15)
• Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling. (2002-04-12)
• Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells. (2012-09-05)
• Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells. (2006-03-28)
• The autophagy enhancer spermidine reverses arterial aging. (2013-04-20)

Authors

• Rui-Hai Zhou
• Aleksandr E Vendrov
• Igor Tchivilev
• Xi-Lin Niu
• Kimberly C Molnar
• Mauricio Rojas
• Jacqueline D Carter
• Haiyan Tong
• George A Stouffer
• Nageswara R Madamanchi
• Marschall S Runge

Publication date

2012-02-20

Journal

Journal topics

• Arteriosclerosis
• Thrombosis
• Vascular Diseases

Language

Eng.

Copyright

Arteriosclerosis, thrombosis, and vascular biology

McAllister Heart Institute, Department of Medicine, 125 MacNaider Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7005, USA.

Release reference

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):745-55

Related books

• Books of Actins
• Books of Age Factors
• Books of Aging
• Books of Animals
• Books of Aorta
• Books of Aortic Diseases
• Books of Apoptosis
• Books of Arteriosclerosis
• Books of Cells, Cultured
• Books of Collagen Type I
• Books of Compliance
• Books of Disease Models, Animal
• Books of Elastin
• Books of Forkhead Transcription Factors
• Books of Genotype
• Books of Hydrogen Peroxide
• Books of Insulin-Like Growth Factor I
• Books of Matrix Metalloproteinase 2
• Books of Mice
• Books of Mice, Inbred C57BL
• Books of Mice, Knockout
• Books of Mitochondria
• Books of Mitogen-Activated Protein Kinase 8
• Books of Muscle, Smooth, Vascular
• Books of Myocytes, Smooth Muscle
• Books of NADPH Oxidase
• Books of Oxidative Stress
• Books of Phenotype
• Books of Proto-Oncogene Proteins c-akt
• Books of Pulsatile Flow
• Books of Stroke Volume
• Books of Superoxide Dismutase
• Books of Superoxides
• Books of Thrombosis
• Books of Transfection
• Books of Ultrasonography, Doppler, Pulsed
• Books of Vascular Diseases
• Books of Vasodilation
• Books of Ventricular Function, Left
• Books of Ventricular Pressure