Vascular incorporation of endothelial colony-forming cells is essential for functional recovery of murine ischemic tissue following cell therapy.

Abstract

Endothelial-specific suicide gene technology demonstrates distinct mechanisms for ECFCs and MSCs, with complete abolishment of ECFC-mediated effects, whereas MSC-mediated effects remained unaffected.

These data strengthen the notion that a dual-cell-based therapy represents a promising approach for vascular regeneration of ischemic tissue.

Full Text

• DOI - Arteriosclerosis, thrombosis, and vascular biology (DOI)
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Subjects

• Animals
• Cell Proliferation
• Endothelium, Vascular
• Female
• Ganciclovir
• Hindlimb
• Humans
• Ischemia
• Mesenchymal Stem Cells
• Mice
• Mice, Nude
• Models, Animal
• Neovascularization, Physiologic
• Phenotype
• Recovery of Function
• Stem Cells
• Tissue Therapy

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Authors

• Theresa M Schwarz
• Simon F Leicht
• Tamara Radic
• Iker Rodriguez-Araboalaza
• Patrick C Hermann
• Frank Berger
• Jaimy Saif
• Wolfgang Böcker
• Joachim W Ellwart
• Alexandra Aicher
• Christopher Heeschen

Publication date

2012-01-19

Journal

Journal topics

• Arteriosclerosis
• Thrombosis
• Vascular Diseases

Language

Eng.

Copyright

Arteriosclerosis, thrombosis, and vascular biology

Stem Cell & Cancer Group, Centro Nacional de Investigaciones Oncológicas, c/ Melchor Fernández Almagro 3, 28029 Madrid, Spain.

Release reference

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):e13-21

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