PGD2 induces eotaxin-3 via PPARγ from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis.

Abstract

The PGD(2)/PGJ(2)-peroxisome proliferator-activated receptor gamma pathway induces eotaxin production from sebocytes, which may explain the massive eosinophil infiltrates observed around pilosebaceous units in EPF.

Full Text

• DOI - The Journal of allergy and clinical immunology (DOI)
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Subjects

• Anilides
• Carbazoles
• Cell Line
• Cells, Cultured
• Chemokines, CC
• Eosinophilia
• Eosinophils
• Fibroblasts
• Folliculitis
• Humans
• Hydantoins
• Keratinocytes
• PPAR gamma
• Prostaglandin D2
• RNA, Messenger
• RNA, Small Interfering
• Receptors, Prostaglandin
• Sebaceous Glands
• Skin Diseases, Vesiculobullous
• Sulfonamides
• Transfection

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Authors

• Kyoko Nakahigashi
• Hiromi Doi
• Atsushi Otsuka
• Tetsuya Hirabayashi
• Makoto Murakami
• Yoshihiro Urade
• Hideaki Tanizaki
• Gyohei Egawa
• Yoshiki Miyachi
• Kenji Kabashima

Publication date

2012-01-30

Journal

Journal topics

• Allergy and Immunology
• Hypersensitivity

Language

Eng.

Copyright

The Journal of allergy and clinical immunology

Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Release reference

J Allergy Clin Immunol. 2012 Feb;129(2):536-43

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